2,6-Di(heteroarylvinyl)pyridines as new potential antitumor agents

Authors
Fichera, M Gregoli, L Musumarra, G
Citation
M. Fichera et al., 2,6-Di(heteroarylvinyl)pyridines as new potential antitumor agents, J PHYS ORG, 13(6), 2000, pp. 344-346
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
ISSN journal
08943230 → ACNP
Volume
13
Issue
6
Year of publication
2000
Pages
344 - 346
Database
ISI
SICI code
0894-3230(200006)13:6<344:2ANPAA>2.0.ZU;2-1
Abstract
A circular dichroism spectroscopic study on the DNA binding ability of 2,6- di(heteroarylvinyi)pyridines (heteroaryl 2-furyl, 2-pyridyl, 2-thiazolyl) p rovided evidence for the binding of the furyl and thiazolyl derivatives to selected oligonucleotides. The furyl derivative, exhibiting logIC(50) = -6. 54 for in vitro inhibition against breast carcinoma cells (MCF-7), might re present a new lead compound for structure optimization. Copyright (C) 2000 John Wiley & Sons, Ltd.