Twenty healthy elderly subjects (12 female, 8 male; mean age 81 years, rang
e 67-87 years) each experienced a 15-day time isolation protocol in which t
hey lived individually in a special laboratory apartment in Which sleep and
circadian rhythm measures could be taken. There were two experiments: one
(6 females, 4 males) involved a 6-h phase advance of the sleep/wake cycle,
and the other (6 females, 4 males) a 6-h phase delay. Each started with 5 b
aseline days, immediately followed by the phase shift. The subject was then
held to the phase shifted routine for the remainder of the study. Rectal t
emperatures were recorded minute-by-minute throughout the entire experiment
and each night of sleep was recorded using polysomnography. A directional
asymmetry in phase-shift effects was apparent, with significantly more slee
p disruption and circadian rhythm amplitude disruption after the phase adva
nce than after the phase delay. Sleep disruption was reflected in reduced t
ime spent asleep, and in changed REM latency, which increased in the phase
advance direction but decreased in the phase delay direction. Although the
phase advance led to a significant increase in wakefulness in the first hal
f of the night, the phase delay did not lead to an equivalent increase in w
akefulness during the second half of the night. Examination of both raw and
'demasked' circadian rectal temperature rhythms confirmed that phase adjus
tment was slow in both directions, but was less slow (and more monotonic) a
fter the phase delay than after the phase advance. Subjective alertness suf
fered more disruption after the phase advance than after the phase delay.