The relationship between mortality from breast cancer and the levels of cal
cium and magnesium in drinking water was examined using an ecological desig
n. The study area consisted of 252 municipalities in Taiwan. Data on the le
vels of calcium and magnesium in drinking water were collected from the Tai
wan Water Supply Corporation (TWSC). The age-standardized mortality rate (A
SR) for breast cancer (1982-1991) was compared among municipalities with di
fferent levels of magnesium and calcium in drinking water. Weighted multiva
riate regression analysis was used, and after adjusting for fertility rates
and urbanization, there was a significant inverse relationship between the
levels of calcium and magnesium in drinking water and risk of death from b
reast cancer.