Case Report: A 40-year-old schizophrenic man was found unconscious, with co
nstricted pupils, sinus tachycardia, and twitching of the limbs. There were
signs of lung infection, which was treated with antibiotics, and mild rhab
domyolysis, De regained consciousness over 8 hours, and reported taking 3-4
g clozapine, Recovery was uneventful. Measured peak clozapine and norcloza
pine concentrations were 3.53 mg/L and 0.70 mg/L, respectively. The concent
ration-time curves were biphasic, with secondary peaks at approximately 36
hours postadmission, Terminal elimination half-lives were 16.9 hours and 22
.5 hours for clozapine and norclozapine, respectively. Conclusion: Clozapin
e and its metabolite norclozapine can show biphasic plasma concentration-ti
me curves after overdosage.