Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes

Authors
Severino, ME Sipsas, NV Nguyen, PT Kalams, SA Walker, BD Johnson, RP Yang, OO
Citation
Me. Severino et al., Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes, J VIROLOGY, 74(14), 2000, pp. 6695-6699
Citations number
40
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
74
Issue
14
Year of publication
2000
Pages
6695 - 6699
Database
ISI
SICI code
0022-538X(200007)74:14<6695:IOHIVT>2.0.ZU;2-S
Abstract
We demonstrate that human immunodeficiency virus type I (HIV-1)-specific CD 8(+) cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary ly mphocytes, monocytes, and dendritic cells individually. Viral inhibition is significantly diminished in lymphocyte-dendritic cell dusters, suggesting that these clusters in vivo could be sites where viral replication is more difficult to control by CTL.