Anti-adhesive activity of sulphated exopolysaccharides of microalgae on attachment of red sore disease-associated bacteria and Helicobacter pylori totissue culture cells

Because of the affinity of certain bacterial species for sulphated glycocon jugates exposed on the epithelial cells of susceptible hosts, we hypothesiz ed that sulphated exopolysaccharides of microalgae can be used in anti-adhe sive therapies against bacterial infections, both in cold- and warm-blooded animals. In this study we found that adhesion of the human pathogen Helico bacter pylori to the HeLa S3 cell line, and adhesion of the fish pathogens Vibrio campbellii, V. ordalii, Streptococcus saprophyticus, and Aeromonas v eronii to spotted sand bass primary tissue culture cells, can be effectivel y blocked with the various sulphated exopolysaccharides used.