Synthesis and antiinflammatory and anticancer activity evaluation of some condensed pyrimidines

Upon condensation with 4-isothiocyanato-4-methyl-2-pentanone, 2,3-diaminona phthalene and N-aminoethyladenosine gave in good yields substituted pyrimid onaphthoimidazole and imidazopyrimidine thione. Refluxing pyrimidobenzthiaz ole with methanol H2SO4 at pH similar to 1 resulted in S-methyl pyrimidoben zthiazole in moderate yield. Pyrimidobenzimidazole derivatives could be rea cted to S-alkylated and N-acylated derivatives by refluxing with ethyl brom oacetate in the presence of anhydrous potassium carbonate in THF and by hea ting in an acetic acid/acetic anhydride mixture. Heating of pyrimidobenzimi dazole with 75% aqueous H2SO4 on a water bath ended up in a rearranged prod uct. All compounds gave correct H-1 MMR, IR, and HR mass spectra. Results o f antiinflammatory, analgesic, and anticancer activity screening of the new compounds are described.