Synthesis and anticancer, antiinflammatory, and analgesic activity evaluation of some sulfa drug and acridine derivatives

Various sulfa drugs were condensed with 4-isothiocyanato-4-methyl-2-pentano ne at pH similar to 3-5 by refluxing in methanol to give various substitute d mercaptopyrimidines. On condensation with 9-chloro-2-substituted or -unsu bstituted acridines, sulfathiazole gave the corresponding condensed product s. N-Ethylaminoadenosine reacted with 9-chloroacridine to the coupled produ ct. Condensation of sulfathiazole with 9-isothiocyanato-2,4-substituted or -unsubstituted acridines afforded the corresponding condensed compounds. Th e structures of all synthesized compounds were confirmed by spectroscopic m ethods. Anticancer, antiinflammatory, and analgesic activities of all compo unds were investigated.