How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies

The epsilon 4 allele of apolipoprotein E is a risk factor for Alzheimer's d isease, but also a modulator of its clinical picture. In this paper, recent research in neuroimaging of aging and Alzheimer's disease in relation to a polipoprotein E is reviewed, emphasizing the advances but also the controve rsies. Further, the possible clinicopathological implications of these find ings are discussed. (C) 2000 Elsevier Science Inc. All rights reserved.