Therapeutic angiogenesis, in the form of growth factor protein administrati
on or gene therapy, is a new method of treatment for patients with severe c
oronary and peripheral artery disease not amenable to conventional methods
of revascularization. Furthermore, a new experimental strategy increases en
dogenous angiogenesis in ischemic tissue to induce local 'angiogens' by mea
ns of electromagnetic stimulation. Further studies examining the molecular
basis and clinical efficacy of electromagnetic angiogenesis are necessary.