Temporal changes in expression of neuronal nitric oxide synthase mRNA in the rat hippocampus associated with kainate-induced seizures

Authors
Kashihara, K Akiyama, K Kodama, M Kohira, I Abe, K
Citation
K. Kashihara et al., Temporal changes in expression of neuronal nitric oxide synthase mRNA in the rat hippocampus associated with kainate-induced seizures, NEUROL RES, 22(4), 2000, pp. 409-412
Citations number
23
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROLOGICAL RESEARCH
ISSN journal
01616412 → ACNP
Volume
22
Issue
4
Year of publication
2000
Pages
409 - 412
Database
ISI
SICI code
0161-6412(200006)22:4<409:TCIEON>2.0.ZU;2-M
Abstract
We studied the temporal changes in expression of neuronal nitric oxide (NO) synthase (nNOS) mRNA in the hippocampus of rats treated with kainic acid b y use of in situ hybridization technique. Intraperitoneal injection of 10 m g kg(-1) kainic acid decreased expression of nNOS mRNAs in the dentate gyru s and CA3 region of the hippocampus at 3 h and 8 h and increased it in the dentate gyrus and CA1 at one week after treatment. Although our previous st udy indicated that administration of kainic acid increased NO generation in the rat hippocampus, present results suggest that the injection of kainic acid results in differential regulation of nNOS mRNA and NO formation in th e rat hippocampus.