Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain

Long-term effects of novel atypical antipsychotic drugs on monoamine transp orters are unknown. We compared labeling of dopamine (DAT) and serotonin (S ERT) transporter proteins in subregions of rat corpus striatum by quantitat ive auto radiography with [H-3]2-beta-carbomethoxy-3-beta-[4'-iodophenyl]tr opane ([H-3]beta-CIT) and [H-3]paroxetine after 28 days of continuous subcu taneous infusion of olanzapine, quetiapine, risperidone, or vehicle control s. Drug treatment did not significantly alter the abundance of either trans porter type in caudate-putamen or nucleus accumbens, indicating that transp orter proteins required to inactivate synaptically released dopamine and se rotonin resist adaptations to longterm treatment with novel antipsychotics that affect neurotransmission by these amines. (C) 2000 Elsevier Science Ir eland Ltd. All rights reserved.