Ionic current model of rabbit retinal horizontal cell

We propose a mathematical model of rabbit retinal horizontal cell based on the ionic current mechanisms. Five types of ionic currents in rabbit retina l horizontal cell, I-Na, I-Ca, I-Kv, I-A and I-Ka, are described by Hodgkin -Huxley type equations based on voltage clamp measurements. In simulation t he model reproduced similar responses to voltage and current clamp experime nts. Under the current clamp experiment a repetitive action potential was f ound on A-type rabbit horizontal cells. Our result suggests that the repeti tive action potential is generated by an interaction Of I-Ca and I-Kv. (C) 2000 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All r ights reserved.