Beef allergy was poorly known before the '90s. Since then, a number of pape
rs appeared elucidating the nature, epidemiology, and symptoms of beef alle
rgy in children allergic to cow's milk and children suffering from atopic d
ermatitis. It is now clear that beef allergy is not an infrequent occurrenc
e, with an incidence between 3.28% and 6.52% among children with atopic der
matitis, its incidence may be as much as 0.3% in the general population. A
diagnosis of beef allergy must be supported by skin prick tests, RASTs, and
challenges. The specificity and sensitivity according to type of test and
the type of extract, however, remains to be evaluated. Despite the fact tha
t other allergens can be sensitizing, the major beef allergen is bovine ser
um albumin (BSA). Beef-sensitive children are also sensitized to ovine seru
m albumin, as well as to other serum albumins; therefore, the use of altern
ative meats in beef-allergic children must be carefully evaluated on an ind
ividual basis. Because industrial heat processing is more efficient than do
mestic cooking in reducing reactivity in beef-sensitive children, freeze-dr
ying and homogenization may support the introduction of processed beef into
the diet of beef-allergic children. Nutrition 2000;16:454-457. (C)Elsevier
Science Inc.