Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation

Authors
Cascante, M Centelles, JJ Veech, RL Lee, WNP Boros, LG
Citation
M. Cascante et al., Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation, NUTR CANCER, 36(2), 2000, pp. 150-154
Citations number
32
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
ISSN journal
01635581 → ACNP
Volume
36
Issue
2
Year of publication
2000
Pages
150 - 154
Database
ISI
SICI code
0163-5581(2000)36:2<150:ROT(BA>2.0.ZU;2-N
Abstract
Metabolic control analysis predicts that stimulators of transketolase enzym e synthesis such as thiamin (vitamin B-1) support a high rate of nucleic ac id ribose synthesis necessary for tumor cell survival, chemotherapy resista nce, and proliferation. Metabolic control analysis also predicts that trans ketolase inhibitor drugs will have the opposite effect on tumor cells. This may have important implications in the nutrition and future treatment of p atients with cancer.