Polyaromatic scavenger reagents (PAHSR): A new methodology for rapid purification in solution-phase combinatorial synthesis

Authors
Warmus, JS da Silva, MI
Citation
Js. Warmus et Mi. Da Silva, Polyaromatic scavenger reagents (PAHSR): A new methodology for rapid purification in solution-phase combinatorial synthesis, ORG LETT, 2(13), 2000, pp. 1807-1809
Citations number
28
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
13
Year of publication
2000
Pages
1807 - 1809
Database
ISI
SICI code
1523-7060(20000629)2:13<1807:PSR(AN>2.0.ZU;2-P
Abstract
A new method of purification of solution-phase combinatorial libraries has been developed. Development of a chemically inert polyaromatic anchor with a reactive "scavenger reagent" (PAHSR) allows unreacted reagents and impuri ties to be removed from a reaction by absorption of the PAHSR to charcoal a nd simple filtration.