An imine addition/ring-closing metathesis approach to the spirocyclic coreof halichlorine and pinnaic acid

Authors
Wright, DL Schulte, JP Page, MA
Citation
Dl. Wright et al., An imine addition/ring-closing metathesis approach to the spirocyclic coreof halichlorine and pinnaic acid, ORG LETT, 2(13), 2000, pp. 1847-1850
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
13
Year of publication
2000
Pages
1847 - 1850
Database
ISI
SICI code
1523-7060(20000629)2:13<1847:AIAMAT>2.0.ZU;2-P
Abstract
An approach to the spirocyclic core of halichlorine and pinnaic acid has be en designed around an imine allylation/ring-closing metathesis sequence. Th is sequence has been used to generate several azabicylo[n.5] model systems. A newly reported metathesis catalyst was show to be highly effective for c yclization of these systems.