Staudinger ligation: A peptide from a thioester and azide

Authors
Nilsson, BL Kiessling, LL Raines, RT
Citation
Bl. Nilsson et al., Staudinger ligation: A peptide from a thioester and azide, ORG LETT, 2(13), 2000, pp. 1939-1941
Citations number
50
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
13
Year of publication
2000
Pages
1939 - 1941
Database
ISI
SICI code
1523-7060(20000629)2:13<1939:SLAPFA>2.0.ZU;2-4
Abstract
The technique of native chemical ligation enables the total chemical synthe sis of proteins. This method is limited, however, by an absolute requiremen t for a cysteine residue at the ligation juncture. Here, this restriction i s overcome with a new chemical ligation method in which a phosphinobenzenet hiol is used to link a thioester and azide. The product is an amide with no residual atoms.