Ethylzincation of monosubstituted alkenes catalyzed by EtMgBr-Cl2ZrCp2 andpalladium-catalyzed cross coupling of the resultant diisoalkylzinc derivatives
S. Gagneur et al., Ethylzincation of monosubstituted alkenes catalyzed by EtMgBr-Cl2ZrCp2 andpalladium-catalyzed cross coupling of the resultant diisoalkylzinc derivatives, ORGANOMETAL, 19(13), 2000, pp. 2417-2419
The reaction of monosubstituted alkenes with 0.5 molar equiv of Et2Zn in th
e presence of a catalyst generated in situ by treatment of Cl2ZrCp2 with 2
molar equiv of EtMgBr produces regioselectively the corresponding diisoalky
lzincs 1, generally in high yields. Their direct cross coupling with a vari
ety of organic halides in the same reaction vessel can be achieved in good
yields with a catalytic amount of a palladium complex.