Action of ozonized water in preclinical inflammatory models

Ozonized water increases oxygen local tension. The ozone by itself produces inflammatory reactions in lung epithelium. The action of ozonized water du ring the inflammatory process was investigated. In rat paw edema induced by carrageenin, the inflammatory process was stimulated by ozonized water (1. 2 mu g, p.o.) when applied 30 min prior to the induction. In the inflammato ry process induced by Freund's Complete Adjuvant, the ozonized water did no t interfere in the inflammatory reaction. Furthermore, in gastric ulcers mo dels induced by stress, there was a significant reduction in the incidence of ulcers types I, II and III (P < 0.05, Student's t-test). (C) 2000 Academ ic Press.