Leptin-induced decrease in food intake in chickens

The effect of intracerebroventricular (i.c.v.) injection of leptin was inve stigated using broiler and Single Comb White Leghorn (SCWL)-type chickens. These represent relatively fast- and slow-growing birds, respectively. The i.c.v. injection of leptin decreased food intake in both broilers and Legho rns in a dose-dependent manner. The most efficacious dose appeared to be 10 mu g in both types of chickens. Water intake was generally not affected by leptin, indicating that this effect was not due to general malaise. It app ears that leptin can act within the central nervous sytstem of birds to dec rease food intake. (C) 2000 Elsevier Science Inc. All rights reserved.