Prognostic factors associated with congenital cystic adenomatoid malformation of the lung

This study presents 18 cases of prenatally diagnosed congenital cystic aden omatoid malformation (CCAM) to identify potential factors that could predic t prognosis. Comparisons of prenatal parameters were made between fetuses t hat survived and those that died perinatally. It was found that microcystic lesion, bilateral lung involvement and hydrops were each highly correlated with poor prognosis, while neither polyhydramnios nor mediastinal shift wa s significantly associated with had outcome. Fetal interventions were indic ated only in two of the surviving cases: a thoracocentesis and a cysto-amni otic shunt. A therapeutic amniocentesis was performed in one case of polyhy dramnios. The diagnosis of CCAM was histologically confirmed in all cases b y necropsy or by postnatal lobectomy. Copyright (C) 2000 John Wiley & Sons, Ltd.