An abdominal computed tomographic scan was modified by inserting 10 simulat
ed colonic polyps with use of methods that closely mimic the attenuation, n
oise, and polyp-colon wall interface of naturally occurring polyps. A shape
-based polyp detector successfully located six of the 10 polyps. When setti
ngs that enhanced the edge profile of polyps were chosen, eight of 10 polyp
s were detected. There were no false-positive detections. Shape analysis is
technically feasible and is a promising approach to automated polyp detect
ion.