Mesial temporal sclerosis and temporal lobe epilepsy: MR imaging deformation-based segmentation of the hippocampus in five patients

In five patients with mesial temporal sclerosis, the authors verified the p recision and reproducibility of hippocampal segmentations with deformation- based magnetic resonance (MR) imaging. The overall percentage overlap betwe en automated segmentations was 92.8% (SD, 3.5%), between manual segmentatio ns was 73.1% (SD, 9.5%), and between automated and manual segmentations was 74.8%(SD, 10.3%). Deformation-based hippocampal segmentations provided a p recise method of hippocampal volume measurement in this patient population.