There is an increasing demand for systems that can automatically analyze im
ages and extract semantically meaningful information. IRIS, an Integrated R
etinal Information system, has been developed to provide medical profession
als easy and unified access to the screening, trend and progression of diab
etic-related eye diseases in a diabetic patient database. This paper shows
how mining techniques can be used to accurately extract features in the ret
inal images. In particular, we apply a classification approach to determine
the conditions for tortuousity in retinal blood vessels.