Integrin-collagen complex: a metal-glutamate handshake

Authors
Bella, J Berman, HM
Citation
J. Bella et Hm. Berman, Integrin-collagen complex: a metal-glutamate handshake, STRUCT F D, 8(6), 2000, pp. R121-R126
Citations number
25
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE WITH FOLDING & DESIGN
ISSN journal
09692126 → ACNP
Volume
8
Issue
6
Year of publication
2000
Pages
R121 - R126
Database
ISI
SICI code
0969-2126(20000615)8:6<R121:ICAMH>2.0.ZU;2-P
Abstract
The recently determined crystal structure of the complex between an integri n I domain and a synthetic collagen peptide shows a collagen triple-helix e ngaged in specific macromolecular recognition and binding. This structure c onfirms a previously proposed binding mechanism for integrin I domains and has important implications for integrin activation and signalling.