Bulk acoustic wave sensor using molecularly imprinted polymers as recognition elements for the determination of pyrimethamine

A new bulk acoustic wave (BAW) sensor modified with a molecularly imprinted polymer (MIP) was fabricated and applied for the: determination of pyrimet hamine. This sensor exhibited high selectivity and sensitive response to py rimethamine. Factors such as pH and the amount of coating influencing senso r properties, were investigated in detail and optimized. The calibration cu rve was linear in the range 6.0 x 10(-7)-1.0 x 10(-4) M. The determination limit was 2.0 x 10(-7) M. In harsh chemical environments such as high tempe rature, organic solvents, bases, acids, etc., the sensor still exhibited lo ng-term stability. The proposed method has been satisfactorily applied for the determination of pyrimethamine in serum and urine media. (C) 2000 Elsev ier Science B.V. All rights reserved.