Application of a new chiral stationary phase containing the glycopeptide antibiotic A-40,926 in the direct chromatographic resolution of beta-amino acids

Authors
D'Acquarica, H Gasparrini, F Misiti, D Zappia, G Cimarelli, C Palmieri, G Carotti, A Cellamare, S Villani, C
Citation
H. D'Acquarica et al., Application of a new chiral stationary phase containing the glycopeptide antibiotic A-40,926 in the direct chromatographic resolution of beta-amino acids, TETRAHEDR-A, 11(11), 2000, pp. 2375-2385
Citations number
47
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
11
Year of publication
2000
Pages
2375 - 2385
Database
ISI
SICI code
0957-4166(20000616)11:11<2375:AOANCS>2.0.ZU;2-4
Abstract
A new enantioselective HPLC procedure for the direct resolution of p-amino acids is described, based on the use of a new chiral stationary phase (CSP) containing the macrocyclic glycopeptide antibiotic A-40,926, structurally related to teicoplanin. covalently bonded to silica gel microparticles. The new CSP shows higher enantioselectivity and broader applicability in this field compared to the parent teicoplanin phase. The potential for semi-prep arative separations on the A-40,926-CSP is demonstrated for a selected cycl ic beta-amino acid. (C) 2000 Published by Elsevier Science Ltd.