New phosphoramidite and phosphito-N chiral ligands based on 8-substituted quinolines and (S)-binaphthol; applications in the Cu-catalyzed enantioselective conjugate addition of diethylzinc to 2-cyclohexen-1-one

Authors
Arena, CG Calabro, G Francio, G Faraone, F
Citation
Cg. Arena et al., New phosphoramidite and phosphito-N chiral ligands based on 8-substituted quinolines and (S)-binaphthol; applications in the Cu-catalyzed enantioselective conjugate addition of diethylzinc to 2-cyclohexen-1-one, TETRAHEDR-A, 11(11), 2000, pp. 2387-2392
Citations number
35
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
11
Year of publication
2000
Pages
2387 - 2392
Database
ISI
SICI code
0957-4166(20000616)11:11<2387:NPAPCL>2.0.ZU;2-Z
Abstract
The copper(II)-catalyzed enantioselective conjugate addition of diethylzinc to 2-cyclohexen-1-one, in the presence of phosphoramidite, and of phosphit o-N chiral ligands, derived From X-chloroquinoline or 8-hydroxyquinoline an d (S)-4-chloro-3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']binaphthalene, re sulted in ee's of 70 and 51% , respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.