Atopy, lung function, and obstructive airways disease after prenatal exposure to famine

Background-Associations have been found between a large head size at birth and atopy, and between low birth weight and obstructive airways disease. A study was undertaken of people born around the time of the Dutch famine in 1944-5 to determine the effects of maternal malnutrition during specific pe riods of gestation on the prevalence of obstructive airways disease and ato py. Methods-Nine hundred and twelve people aged about 50, born at term between November 1943 and February 1947 in Amsterdam, were asked about their medica l history. Lung function was measured in 733 and serum concentrations of to tal IgE and specific IgE against mite, pollen and cat were measured in 726. Those exposed in late, mid, and early gestation (exposed participants) wer e compared with those born before or conceived after the famine (non-expose d participants). Results-Exposure to famine during gestation affected neither the concentrat ions of total or specific IgE nor lung function values. The prevalence of o bstructive airways disease was increased in people exposed to famine in mid gestation (odds ratio adjusted for sex 1.7, 95% confidence interval (CI) 1 .1 to 2.6) and tended to be higher in those exposed in early gestation (odd s ratio 1.5, 95% CI: 0.9 to 2.6). Conclusions The observed increase in the prevalence of obstructive airways disease in people exposed to famine in mid and early gestation was not para llelled by effects on IgE concentrations or lung function. The link between exposure to famine in mid and early gestation and obstructive airways dise ase in adulthood suggests that fetal lungs can be permanently affected by n utritional challenges during periods of rapid growth.