MULTIPLE ENDOCRINE NEOPLASMS IN A PATIENT WITH AL AMYLOIDOSIS-ASSOCIATED PLASMA-CELL DYSCRASIA

Reports on patients with systemic amyloidosis-associated plasma cell d yscrasia (PCD) who have multiple endocrine tumors are very rare. Here we describe such a case. The patient was a 74-yr-old man with amyloid light-chain (AL) amyloidosis-associated PCD who had a null-cell adenom a of the pituitary and a latent papillary carcinoma of the thyroid gla nd, as well as a tubular adenoma of the sigmoid colon. The amyloid pro tein deposits reacted with the antibody to the lambda-immunoglobulin l ight chain. Since PCD by itself may be a risk factor for the developme nt of subsequent neoplasms, the careful clinical evaluation of PCD pat ients is recommended.