Murine models of inflammation: role of CD23

The role of IgE in eosinophil recruitment and bronchial hyperresponsiveness has been extensively studied with murine models of inflammation. Many inve stigators using various knockout models have clearly shown that both IgE-de pendent and -independent pathways play a role in eosinophil recruitment and bronchial hyperresponsiveness after allergen challenge, illustrating the c omplexity of airways inflammation. The expression of this response is likel y to involve many interacting pathways, and it will be a considerable chall enge to determine key points within these pathways that will yield novel ta rgets for future therapeutic strategies.