A prospective, randomized, controlled trial of high and low maintenance doses of magnesium sulfate for acute tocolysis

OBJECTIVE: This study was undertaken to compare a high-dose protocol for ma gnesium sulfate tocolytic therapy with a low-dose regimen with respect to t ime needed to achieve tocolysis. STUDY DESIGN: Patients between 24 and 34 weeks' gestation with preterm labo r were included. Patients with ruptured membranes or nonreassuring fetal as sessments were excluded. Gravid women received a 4-9 loading dose of magnes ium sulfate and were prospectively randomly assigned to receive a maintenan ce dose of 2 or 5 g/h. RESULTS: The median times to tocolysis were 120 minutes (semi-interquartile range, 30 minutes) in the low-dose group and 90 minutes (semi-interquartil e range, 28 minutes) in the high-dose group (P < .001). CONCLUSION: Patients treated with a higher maintenance dose of magnesium su lfate had a higher frequency of side effects; however, tocolysis was achiev ed more rapidly and they required shorter admissions to the labor and deliv ery unit without increased maternal or neonatal morbidity.