Beta-globin gene cluster haplotypes in two North American indigenous populations

Haplotypes derived from five polymorphic restriction sites were determined in 50 Carrier-Sekani and 70 Mvskoke chromosomes, and the results were integ rated with those previously obtained for 11 South American Indian populatio ns. Eleven haplotypes were identified in the Mvskokes, while five were obse rved in the Carrier-Sekani. As in South American natives, haplotype 2 (+ - - -) and 6 (- + - +)were the most prevalent among the Mvskoke (46% and 30%, respectively). In the Carrier-Sekani, haplotype 2 was also the most common , but haplotype 5 (- + - + +) was somewhat more frequent (18%) than 6 (12%) . High heterozygosities, as well as genetic differentiation, were observed among these two North American and two other South American groups (Mapuche and Xavante). They could be due to non-Indian admixture in the Mvskoke and Mapuche, but the findings in the other two populations require some other type of explanation. (C) 2000 Wiley-Liss, Inc.