E. Mundo et al., Is the 5-HT1D beta receptor gene implicated in the pathogenesis of obsessive-compulsive disorder?, AM J PSYCHI, 157(7), 2000, pp. 1160-1161
Objective: Obsessive-compulsive disorder (OCD) is a psychiatric condition f
or which strong evidence of a genetic component and serotonergic system inv
olvement exists. Recent studies have shown that sumatriptan, a selective li
gand of the serotonin (5-HT)(1D beta) autoreceptor, modifies OCD symptoms.
The aim of this study was to investigate the presence of linkage disequilib
rium between the 5-HT1D beta receptor gene, which has a variant caused by a
silent G to C substitution at nucleotide 861 of the coding region, and OCD
.
Method: DNA was collected from 67 probands who met DSM-IV criteria for OCD
and from their living parents or siblings. Transmission Disequilibrium Test
/sib-Transmission Disequilibrium Test analyses were then conducted with the
DNA data.
Results: Thirty-two families were informative for the analysis, which showe
d a preferential transmission of the 6 allele to the affected subjects.
Conclusions: If the results are confirmed, there may be important implicati
ons for the 5-HT(1D beta)ceptor gene in the pathogenesis and treatment of O
CD.