Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation - A pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2)

Authors
Harris, M Coyne, J Tariq, M Eyden, BP Atkinson, M Freemont, AJ Varley, J Attwooll, C Telford, N
Citation
M. Harris et al., Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation - A pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2), AM J SURG P, 24(7), 2000, pp. 1020-1026
Citations number
28
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
ISSN journal
01475185 → ACNP
Volume
24
Issue
7
Year of publication
2000
Pages
1020 - 1026
Database
ISI
SICI code
0147-5185(200007)24:7<1020:EMCWND>2.0.ZU;2-1
Abstract
A case of extraskeletal myxoid chondrosarcoma (EMC) in which there was hist ochemical, immunohistochemical, and ultrastructural evidence of neuroendocr ine differentiation is reported. Genetic investigations showed the recently described novel translocation t(9;17)(q22;q11.2) and associated fusion of the CHN and RBP56 genes, contrasting with the translocation t(9;22)(q22;q12 ) and EWS/CHN gene fusion found in the majority of EMCs.