Determination of ofloxacin using a chemiluminescence flow-injection method

A new chemiluminescence (CL) flow-injection method was proposed for the det ermination of ofloxacin in pharmaceuticals in the range 0.04-4 mu g ml(-1) with a detection limit of 0.016 mu g ml(-1) and a relative standard derivat ion (R.S.D.) of 2.2% at 0.4 mu g ml(-1) (n=10). The method is based on the CL reaction of cerium(IV) with sulphite sensitized by ofloxacin. The establ ished procedure could be applied to the determination of ofloxacin in table t, capsule and injection in agreement with the results obtained by using re ported methods. (C) 2000 Elsevier Science B.V. All rights reserved.