Successful treatment and re-treatment of resistant B-cell chronic lymphocytic leukemia with the monoclonal anti-CD 20 antibody rituximab

We report on two patients with chemoresistant B-cell chronic lymphocytic le ukemia who were treated successfully with the monoclonal anti-CD 20 antibod y rituximab. Both patients suffered from severe thrombocytopenia requiring platelet transfusions over a period of several months. Neither chemotherapy nor immunosuppressive agents (corticolds, immunoglobulins) were effective. After four doses of rituximab (375 mg/m(2) weekly), both patients recovere d within a few weeks to hematological partial remission. One patient was re -treated successfully three times after relapses. Both patients were premed icated with prednisone (100 mg) 30 min prior to the infusion to prevent cyt okine release and the antibody infusions were well tolerated.