[F-18] fluorodeoxyglucose positron emission tomography in the diagnosis ofcancer in patients with paraneoplastic neurological syndrome and anti-Hu antibodies

The diagnosis of cancer is often difficult in patients with paraneoplastic neurological syndrome and anti-flu antibodies. Fluorodeoxyglucose 18 positr on emission tomography scanning is a highly sensitive and specific method t o detect lung tumors. We investigated 15 patients with paraneoplastic neuro logical syndrome and anti-Hu antibodies. Radiological methods led to the di agnosis of cancer in 12 patients, and test results were negative in 3. Whol e-body [F-18]fluorodeoxyglucose positron emission tomography showed abnorma l uptake in the mediastinum in these 3 patients in accordance with the expe cted location of the malignancy.