Rhenium-188-labeled anti-neural cell adhesion molecule antibodies with 2-iminothiolane modification for targeting small-cell lung cancer

We have evaluated the potential of Re-188-labeled monoclonal antibodies (MA bs) modified with 2-iminothiolane (2IT) for targeting small-cell lung cance r (SCLC). Radiolabeled MAbs NK1NBL1 and C218 recognizing neural cell adhesi on molecule were injected i.v. into athymic mice inoculated with human SCLC tumors, and the biodistribution was examined. NK1NBL1 localized in the tum ors better than C218. Re-188-labeled MAbs cleared from the blood faster tha n I-125-labeled counterparts, resulting in higher tumor-to-blood ratios. In conclusion, the Re-188-labeled MAbs are attractive candidates for imaging and therapy of SCLC.