Primary living-donor liver transplantation at the University of Chicago - Technical aspects of the first 104 recipients

Objective To evaluate the impact of technical modifications on living-donor liver transplants in children since their introduction in 1989. Summary Background Data Although more than 4,000 liver transplants are perf ormed every year in the United States, only approximately 500 are performed in children. Living-donor liver transplantation has helped to alleviate th e organ shortage for small children in need of liver transplantation. Few c enters have amassed a sufficient number of cases to evaluate the impact of the differ ent techniques used in pediatric living-donor liver transplantat ion. Methods From 1989 through 1997, 104 primary living-donor liver transplants were performed at: the University of Chicago. Three phases of the living-do nor liver transplant program can be defined based on the techniques of vasc ular reconstruction: phase 1, November 1989 to November 1994 (n = 78); phas e 2, November 1994 to January 1996 (n = 6); and January 1996 to present (n = 20). The patients' charts were reviewed retrospectively. The incidence an d type of vascular complications and patient and graft survival rates were analyzed. Results Although the demographics of the patients have not changed during t he three phases of the living-donor liver transplant program, the outcomes have improved. Without the use of conduits, the incidence of portal vein co mplications has significantly decreased from 44% to 8%. The incidence of he patic artery thrombosis has decreased from 22% to 0% with the use of microv ascular techniques, The combined use of both techniques has led to a signif icant increase in graft survival, from 74% to 94%. Conclusions The living-donor liver transplant recipient operation has under gone significant technical changes since its introduction in 1989. These ch anges have decreased the vascular complications associated with this type o f graft. Avoiding the use of vascular conduits and performing microvascular hepatic artery anastomoses are the critical steps in improving graft survi val.