Milrinone for long-term pharmacologic support of the status 1 heart transplant candidates

Background. We determined the efficacy of long-term therapy with milrinone alone or in combination with inotropic agents in status 1 heart transplant candidates as a pharmacological support until heart transplantation. Methods. Hemodynamic and biochemical variables were recorded in 29 status 1 men with symptoms of severe congestive heart failure, who received continu ous intravenous milrinone alone (group 1, n = 21) or in combination with in otropic agents (group 2, n = 8) while awaiting heart transplantation. Results. Symptomatic relief was noted in all patients of both groups withou t any preoperative deaths. One patient (4.8%) of group 1 died on the second day and I patient of group 2 died 16.4 months after transplantation. Altho ugh pulmonary capillary wedge pressure (group 1, p = 0.021; group 2, p = 0. 0002), mean pulmonary artery pressure (group 1, p = 0.051; group 2, p = 0.0 04), and pulmonary vascular resistance (group 1, p = 0.0026; group 2, p = 0 .056) were reduced by 1 hour after the onset of treatment and maintained un changed until transplantation, the changes in mean pulmonary artery pressur e in group 1 and pulmonary vascular resistance in group 2 were statisticall y insignificant except in the posttransplantation period. Conclusions. Long-term therapy with milrinone in combination with inotropic agents is safe and effective when only milrinone infusion is inadequate fo r pharmacologic support in status 1 candidates. (C) 2000 by The Society of Thoracic Surgeons.