It has now been over a quarter of a century since the publication of Mervyn
Susser's Causal Thinking in the Health Sciences (1973, Oxford University P
ress), the first book-length treatment of causal reasoning and inference in
our field. Major contributions of this work were its holistic focus on the
origins of health outcomes in the context of ecologic systems and its invi
goration of the literature on causal criteria in epidemiology. Although a r
ecent resurgence of interest in social context has revivified many points m
ade by Susser, a formal basis for causal analysis consistent with this ecol
ogic perspective has failed to emerge in public health research. Susser's d
iscussion of causal criteria, on the other hand, helped spur a vigorous dia
logue that has persisted unabated to the present day. Although the basic ou
tline of the criteria has evolved little, their applications, interrelation
s, and relative contributions to causal judgments have been the subject of
continued and sometimes contentious debate.