The interaction of chalcones with tubulin

Authors
Lawrence, NJ McGown, AT Ducki, S Hadfield, JA
Citation
Nj. Lawrence et al., The interaction of chalcones with tubulin, ANTI-CAN DR, 15(2), 2000, pp. 135-141
Citations number
29
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTI-CANCER DRUG DESIGN
ISSN journal
02669536 → ACNP
Volume
15
Issue
2
Year of publication
2000
Pages
135 - 141
Database
ISI
SICI code
0266-9536(200004)15:2<135:TIOCWT>2.0.ZU;2-K
Abstract
The chalcone 3,4,3',4',5'-pentamethoxychalcone is a potent cytotoxic agent. A series of chalcones and (E)-4-(4'-hydroxyphenyl)but-3-en-2-one were prep ared and assessed for their ability to inhibit cell growth in vitro. The cy totoxicity correlates with their ability to bind to tubulin as measured by immunofluorescence, cell cycle analysis and disruption of microtubule assem bly. Some of the chalcones were shown to bind to the type II oestrogen rece ptor.