Ninety-mo strains of Yersinia pestis recovered over a 21-year period were e
valuated for susceptibility to traditional and newer antimicrobial agents.
In vitro resistance was noted only against rifampin and imipenem (similar t
o 20% of strains). The most active compounds (MIC at which 90% of the isola
tes tested are inhibited) against Y. pestis were cefixime, ceftriaxone, tri
methoprim-sulfamethoxazole, and trovafloxacin.