Direct measurement of the anti-influenza agent zanamivir in the respiratory tract following inhalation

Authors
Peng, AW Milleri, S Stein, DS
Citation
Aw. Peng et al., Direct measurement of the anti-influenza agent zanamivir in the respiratory tract following inhalation, ANTIM AG CH, 44(7), 2000, pp. 1974-1976
Citations number
17
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
7
Year of publication
2000
Pages
1974 - 1976
Database
ISI
SICI code
0066-4804(200007)44:7<1974:DMOTAA>2.0.ZU;2-F
Abstract
in a single-center, randomized study, zanamivir (Relenza) concentrations in induced sputum samples and nasal washings of healthy adults following oral inhalation were measured. Concentrations in sputum exceeded the median vir al neuraminidase 50% inhibitory concentration at 6, 12, and 24 h, and those in nasal washings did so at 6 and 12 h. There were no zanamivir-related ad verse events or laboratory abnormalities.