Citation
G. Balboni et al., Synthesis and binding of 3-aminopyridine derivatives at central nicotinic receptors, ARZNEI-FOR, 50(6), 2000, pp. 507-511
Citations number
19
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172
→ ACNP
Volume
50
Issue
6
Year of publication
2000
Pages
507 - 511
Database
ISI
SICI code
0004-4172(200006)50:6<507:SABO3D>2.0.ZU;2-3
Abstract
A series of secondary and tertiary pyridyl amides as potential central nico
tinic acetylcholine receptors (nAChRs) ligands were prepared. Amides displa
yed negligible or very low affinity, whereas two amines achieved by reducti
on of corresponding secondary amides, showed affinity in the nanomolar rang
e for nAChRs.