Synthesis and antisecretory activity of 6-substituted 5-cyanomethylimidazo[2,1-b]-thiazoles and 2,6-dimethyl-5-hydroxymethyl imidazo[2,1-b][1,3,4]thiadiazole

Authors
Andreani, A Leoni, A Locatelli, A Morigi, R Rambaldi, M Simon, WA Senn-Bilfinger, J
Citation
A. Andreani et al., Synthesis and antisecretory activity of 6-substituted 5-cyanomethylimidazo[2,1-b]-thiazoles and 2,6-dimethyl-5-hydroxymethyl imidazo[2,1-b][1,3,4]thiadiazole, ARZNEI-FOR, 50(6), 2000, pp. 550-553
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
50
Issue
6
Year of publication
2000
Pages
550 - 553
Database
ISI
SICI code
0004-4172(200006)50:6<550:SAAAO6>2.0.ZU;2-1
Abstract
The synthesis of imidazo[2,1-b]thiazole and imidazo[2,1-b][1,3,4]thiadiazol e derivatives, related to known antiulcer agents, is reported. 5-Cyanomethy l-6-methylimidazo[2,1-b]thiazole showed significant antisecretory activity in the isolated rabbit gastric glands assay.