Citation
M. Marastoni et al., Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors, ARZNEI-FOR, 50(6), 2000, pp. 564-568
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172
→ ACNP
Volume
50
Issue
6
Year of publication
2000
Pages
564 - 568
Database
ISI
SICI code
0004-4172(200006)50:6<564:SAAONA>2.0.ZU;2-F
Abstract
A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 =
165 nmol/l) with structural modifications at P1/P1' substituents or with a
lengthening at its core unit were synthesized from amino acid starting mat
erials. All analogues were less active than Pc against the protease.