Activation of NADPH oxidase in Alzheimer's disease brains

Authors
Shimohama, S Tanino, H Kawakami, N Okamura, N Kodama, H Yamaguchi, T Hayakawa, T Nunomura, A Chiba, S Perry, G Smith, MA Fujimoto, S
Citation
S. Shimohama et al., Activation of NADPH oxidase in Alzheimer's disease brains, BIOC BIOP R, 273(1), 2000, pp. 5-9
Citations number
19
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
273
Issue
1
Year of publication
2000
Pages
5 - 9
Database
ISI
SICI code
0006-291X(20000624)273:1<5:AONOIA>2.0.ZU;2-N
Abstract
The present study is the first to show that superoxide (O-2(-)) forming NAD PH oxidase is activated in Alzheimer's disease (AD) brains by demonstrating the marked translocation of the cytosolic factors p47-phox and p67-phox to the membrane. In conjunction with a recent in vitro study showing that amy loid beta activates O-2(-) forming NADPH oxidase in microglia, where these phox proteins are localized in this study, the present results suggest that , in AD, NADPH oxidase is activated in microglia, resulting in the formatio n of reactive oxygen species which can be toxic to neighboring neurons in A D. (C) 2000 Academic Press.